Lornoxicam, a potent non-steroidal anti-inflammatory drug which has short half life, which formulates the sustained release dosage forms advantages. Therefore the present investigation was concerned with the development of the sustained release matrix tablets using hydrophilic and hydrophobic polymers, which after oral administration were designed to prolong the duration of action. Lornoxicam Sustained release matrix tablet was prepared by wet granulation method using Acrypol 912G and Eudragit RSPO in formulation. FTIR and DSC study showed that there is no change in lornoxicam crystal form. The dissolution profile of the most satisfactory batch was fitted to zero-order, first-order, Higuchi, Hixson Crowell and K-Peppas models to ascertain the kinetic modelling of drug release. From the result it was observed that the combination ratio of Acrypol 912G and Eudragit RSPO have distinct effect on in vitro drug release profile. Release rate of lornoxicam was decrease with increased the total polymer concentration. Mechanism of drug release was explained by K-Peppas equation and found that diffusion-erosion occurs by anomalous transport (non-Fickian) release was predominant.
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